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Turret Exchangeability
The AQUARIUS series provides turret exchangeability as a standard feature. Our Turret Swing Arm System / Turret Exchange Rail System makes a turret change a quick and simple task. This feature allows for the use of TSM B &TSM D tooling in the same machine, as well as making the machine very easy to clean after use.
The turret exchange SOP is displayed on the OIT to prevent any operator mistakes. This system provides Step-by-Step instructions with safety interlocks, which ensures the operator a quick and easy exchange of the turret. This entire process can be accomplished safely in less than 20 minutes.
Turret Removal 1
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Containment Technology
Access Port
KIKUSUI CONTAINMENT TECHNOLOGY meets the hazardous production requirements in pharmaceutical facilities with potential compounds under the industrial hygiene standard and GMP cross contamination protections.
It achieves easy and flexible disassembling & washing operation in the machine under sufficient working space to minimize exposing potent drug in wetting material as well as operator's inhalation risk.
Body Seamless Construction/Mirror Polish
Access doors equipped with Inflatable seals create high a containment condition inside. Glove ports allow the operator access into the machine during containment conditions. It has an integrated special isolator on the top of the machine with suitable glove ports. The Rapid Transfer Port ensures that contaminated removable parts will be transported safely in a sealed transfer bag.
AQUARIUS Containment also allows for the machines exterior to be washed, protecting operators from high potent drug.
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Water Washing System
High Pressure Water Washing System is available on AQUARIUS Containment press.
The die table, punch bores and die pockets are thoroughly washed automatically using High pressure water supplied by the self contained Water Washing Vacuum Drying unit supplied with the press. Optional rotary washing nozzle is pictured.
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Multi Layer Technology
KIKUSUI MULTI LAYER TECHNOLOGY has been developed for Bi-layer tableting operation from R&D /Lab applications to Production scale. Key features as below.
- Suitable cam track design to produce Multi-layer tablets.
- New Closed Feeder paired with a reliable vacuum system minimizes cross contamination.
- Feeder combination with Closed and Re-circulation gives flexibility and minimizes powder loss.
- Tablet Layer sampling system to check each layer tablet during production.
- Dust seals combined with Bellows will help extend production times.
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Dry Coating Technology
KIKUSUI DRY COATING TECHNOLOGY has been developed for Dry coated operation from R&D /Lab applications to Production scale. Key features as below.
- Suitable cam track design to produce Dry coated tablets.
- Core vibration feeder provides powerful feeding to feed enough cores to transport module.
- Special core transport module supports smooth powder coating operation.
- New Closed Feeder minimizes powder overflow at core insert portion
- Camera visual system inspects not only coreless tablets but also its position with auto regulation.
- Dust seals combined with Bellows will help extend production times.
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External Lubrication Technology
Typical granule/powder blends contain Magnesium Stearate as an internal lubricant to help in the prevention of tablet sticking and reduce die friction. This often results in softer tablets and poor dissolution.
KIKUSUI EXTERNAL LUBRICATION technology is used to spray a measured amount of lubricant onto punch tips and die bores. This creates a film of lubricant on those surfaces. In addition, an Electrostatic generation device charges the lubricant at the spray nozzle to help with coating efficiency. In turn, typical tableting problems that are associated with the use of internal lubricants can be avoided.
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Pressure Control Device (PCD)
There is a proportional relation between tablet weight and compression force when tablet thickness is steady.
KIKUSUI automatic pressure control system (PCD) controls and stabilizes the tablet weight. During main compression, the load cell sends a force wave to the EPCD. After receiving that force wave, it is then digitalized and compared to the Pre-set values. EPCD will then make the necessary adjustments for feed back control. With an air driven, fast action valve, the rejection system ensures targeted tablets are rejected individually. This rejection method will minimize the total number of rejected tablets.
Our Pressure Control Device is also utilized for various types of Punch/Tablet monitoring. To the benefit of the machine operator, the pressure data populates different graphs that can warn you of potential time consuming irregularities
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Pas Data Acquisition System
PAS (PLC based tableting data Acquisition System) is an application to acquire and save the measured data with PCD (Automatic Pressure control device), TT (Tablet Tester) and PLC (Main Programmable Logic Controller) on all of Kikusui presses.
PAS also includes the following functions to be in compliance with 21 CFR Part 11.
- PAS provides password protection to guarantee controlled access. It prevents unlawful access by personnel who do not have any authority on the system. Users are categorized based on user ranks. All of the access trail to the system should be recording on the system.
- Along with acquiring and saving data on the production, PAS also has the ability for save control and adjustment (modification) records of the production. The product recipe is registered with a full audit trail and batch report.
- Second level of tablets weight control and regulation and tablets thickness control and regulation in combination with tablet tester and PCD control, with different option for control and press alarm.
- Different options and possibilities of data, records, and screen visualization and print out, single punch force graphics and trend- statistic report, increased list of products and recipe information (also in combination with tablet tester information and EPCD pressure control), display and print out of audit trail and alarm diagnosis.
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PTOLEMY System
(New Generation Continious Production)
Rotary press pioneer KIKUSUI presents a new generation of pharmaceutical production system, PTOLEMY. PTOLEMY is the integrated continuous production system to aim at reducing production time and cost for solid formulation. It consists of Powder constant feeder (POLARIS), Continuous blender (CRATER ARIES), NIR Blend uniformity checker (SPICA), Rotary tablet press (AQUARIUS series etc) and Built in tablet visual inspection module (AURIGA). Powder constant feeder (POLARIS) provides each raw material with definite quantity to the blending process.
Continuous blender (CRATER ARIES) is the combined system with vertical mixer and Horizontal blender to maximize blending performance and minimize production space.
NIR Blend uniformity checker (SPICA) is real time monitoring for blending uniformity. Rotary tablet press (AQUARIUS series etc) produces the tablets according to the blending yield and condition on upstream process. Built in tablet visual inspection module (AURIGA) transfers produced tablets with sequential order from tablet discharge portion and performs tablet visual inspection by camera.
PTOLEMY SYSTEM allows us to install continues production process of solid formulation from material weighing, blending, Tableting, Dedusting and inspection processing. It is the newest generation of pharmaceutical production system having none scale-up study required and aiming at reducing production time & cost.
